The Importance of Diet and Exercise in the Management of Diabetes Free Essay Example, 3250 words

Secretion from these glands decreases due to wear and tear, antibodies against it or due to failure in adaptation to the long-term demands of peripheral insulin requirement and resistance (Kumar, p. Failure of adaptation occurs due to lipotoxicity, glucotoxicity, and formation of amyloid in the beta cells region. All these accounts to loss of pulsatile and oscillatory pattern of secretion of insulin by beta cells, thus causing loss of attenuation of the rapid phase of insulin secretion which, actually, is the normal response to elevated glucose levels in the blood. As age advances, the mass of beta cells also decreases along with degeneration of the islet, further contributing to decreased insulin secretion (Kumar, p. Lipotoxicity is yet another cause of the gradual decline in the function of beta cells because of the inverse correlation between insulin sensitivity and levels of free fatty acids in the fasting plasma. There is immense research that supports a strong association betwe en insulin resistance and obesity. In fact, central and visceral obesity is strongly associated with risk of diabetes-2 (Kumar, 1195). Also, intracellular triglycerides and raised free fatty acid levels in plasma are potent inhibitors of signaling of the insulin. We will write a custom essay sample on The Importance of Diet and Exercise in the Management of Diabetes or any topic specifically for you Only $17.96 $11.86/page